Sintesis Dan Uji Aktivitas Antioksidan Senyawa Pirazolo-Piridin Analog Kurkumin Monoketon

  • Enda Mora Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
  • Adel Zamri Faculty of Mathematics and Natural Sciences, Universitas Riau
  • Hilwan Y. Teruna Faculty of Mathematics and Natural Sciences, Universitas Riau
  • Neni Frimayanti Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
  • Ihsan Ikhtiarudin Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
  • Noval Herfindo Faculty of Mathematics and Natural Sciences, Universitas Riau
  • Elsa Natia Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
Keywords: Analog kurkumin monoketon, Claisen schmidt, refluks, docking molekuler, DPPH.


 Telah dilakukan sintesis  senyawa pirazolo-piridin analog kurkumin monoketeon dengan dua tahap reaksi. Tahap pertama dilakukan reaksi sintesis analog kurkumin dengan metode microwave dengan prinsip reaksi Claisen-Schmidt. Tahap kedua dengan senayawa analog kurkumin hasil sintesa tahap satu ditambah  phenyl hidrazin memakai metode refluks pada temperatur 800C. Struktur senyawa 1 telah ditetapkan dengan analisis spektroskopi, meliputi spektroskopi UV, FT-IR, 1H-NMR, dan COSY. Uji aktivitas antioksidan dilakukan dengan metode DPPH(1-1diphenyl-2-picryl hydrazyl). Hasil uji aktivitas antioksidan secara in vitro menunjukkan senyawa 1  aktif sebagai anti oksidan dengan nilai IC50; 190,809 µg/ml. Docking molekuler dilakukan menggunakan paket perangkat lunak MOE 2020.09, dan hasil docking molecular, senyawa 1 dapat digunakan sebagai calon antioksidan yang potensial.


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How to Cite
Mora, E., Zamri, A., Teruna, H. Y., Frimayanti, N., Ikhtiarudin, I., Herfindo, N., & Natia, E. (2023). Sintesis Dan Uji Aktivitas Antioksidan Senyawa Pirazolo-Piridin Analog Kurkumin Monoketon. Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta, 2(1), 116-120.